This is the 4-position monomethyl lysine of the 1-21 amino acid histone H3 peptide. Methylation is the starting point of histone methylation. Its chromatin markers are also closely related to the cell type-specific expression of the putative gene targets of enhancers. It has also been noted from genome-wide studies that most potential regulatory elements are only enriched by the monomethylated version of histone 3.
1, Tian Y. et al. PLOS One. 6(11):e27770 (2011). 2, Ortega-Velazquez, R. et al. FASEB. 17, 1529 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys(Me1) - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - OH