This is the 4-position dimethylated lysine of the 1-21 amino acid histone H3 peptide. This histone methylation is characterized by enrichment around the transcription start site (TSS). It was observed that a group of genes related to T cell function showed high levels of H3K4me2 in their genes. Although the enrichment of H3K4me2 in the genome is a feature of yeast-expressed genes, in contrast, H3K4me2 is mainly enriched around mammalian TSS.
1, Tian Y. et al. PLOS One. 6(11):e27770 (2011) 2, Pekowska A. et al. Genome Res. 20, 1493-1502 (2010).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys(Me2) - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - OH