This is histone H3 (23-34) trimethylated at Lys27 and biotinylated at the C-terminus via a GGK linker. The trimethylation of Lys27 promotes the binding of polycystin (Pc) chromatin. This modification has also been shown to be related to methylated CpG island genes in cancer cells. When the peptide purity is greater than 95%, the peptide is dissolved in distilled water at a concentration of 1 mg/ml, and lyophilized again into a powder form.
Schlesinger, Y. et al. Nat Genet 39, 232 (2007); Zhang, X. et al. Nat Struct Mol Biol 14, 869 (2007); Min, J. et al. Genes Dev 17, 1823 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Lys - Ala - Ala - Arg - Lys(Me3) - Ser - Ala - Pro - Ala - Thr - Gly - Gly - Gly - Gly - Lys(Biotin) - OH