This is histone 3 lysine 36 dimethylated peptide. This peptide has been shown to form a histone deacetylase complex with nucleosomes and inhibit transcription. In addition, due to its epigenetic suppression marker, it allows the demethylation of JMJD5, a member of the Jumonji C domain family, which acts as a transcriptional activator by inhibiting HDAC and regulates cell cycle proliferation.
1, Luco RF. et al. Science, 327:996-1000 (2010) 2, Carrozza MJ. et al. Cell, 123:581-592 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Thr - Lys - Ala - Ala - Arg - Lys - Ser - Ala - Pro - Ala - Thr - Gly - Gly - Val - Lys(Me3) - Lys - Pro - His - Arg - Tyr - Arg - Pro - Gly - Gly - Lys(Biotin) - OH