Melan-A is a melanocyte differentiation antigen recognized by cytotoxic T lymphocytes. This sequence is a naturally occurring Melan-a/MART-1 nonamer peptide. Melan-A/MART-1 gene is expressed in normal melanocytes, as well as most fresh melanoma samples and melanoma cell lines. This peptide is a very common immunogenic epitope of HLA-A2-restricted melanoma-specific tumor infiltrating lymphocytes (TIL), which may contribute to the development of immunotherapy strategies.
Ref: Kawakami, Y. et al. J. Exp. Med 180, 347 (1994); Schneider, J. et al. Int. J. Cancer 75, 451 (1998).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Ala - Gly - Ile - Gly - Ile - Leu - Thr - Val - OH