Autoantigen residues of MGP125 were found in the mouse glycopeptide sequence. This fragment is an H-2Db restricted epitope recognized by CD8+ T cells. Mgp100 is an enzyme usually involved in pigment synthesis, and epitope fragments are usually expressed in normal melanoma cells and melanoma cells.
Finkelstein, S. et al. J Leukoc Biol 76, 333 (2004); Hosoi, A. et al. Cancer Res 68, 3941 (2008); Overwijk, WW. et al. J Exp Med 188, 277 (1998).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Glu - Gly - Ser - Arg - Asn - Gln - Asp - Trp - Leu - OH