Myelin oligodendrocyte glycoprotein (MOG) is a member of the immunoglobulin superfamily and is only expressed in the central nervous system (1-3). MOG (35-55) can induce the production of autoantibodies and relapsing-remitting neurological diseases, leading to extensive plaque-like demyelination (1-2). In patients with multiple sclerosis (MS), MOG (35-55)-induced experimental autoimmune encephalomyelitis (EAE) C57/BL6 mice and Lewis rats (1-4) have been observed to MOG (35-55) 55) Autoantibody reaction.
1. Slavin, A. et al. Autoimmunity 28, 109 (1998). 2. Ichikawa, M. et al. Cellular Immunol 191, 97 (1999). 3. Kennel De March, A. et al. J Neuroimmunol 135, 117 (2003). 4. Robinson, W. et al. Nat Biotech 21, 1033 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Met - Glu - Val - Gly - Trp - Tyr - Arg - Ser - Pro - Phe - Ser - Arg - Val - Val - His - Leu - Tyr - Arg - Asn - Gly - Lys - OH