This peptide is derived from the human mucin MUC5AC gene sequence. Data suggest that MUC5A and MUC5C are part of the same gene MUC5AC, which is distinct from MUC5B. The gene MUC5AC is mainly expressed in gastric, tracheo-bronchial mucosae and some tumors, it exhibits two kinds of deduced peptide domains, one of which is 8 amino acid tandemly repeated domain, a consensus peptide TTSTTSAP.
Duperat, V. et al. Biochem. J. 305, 211 (1995); Ten Hagen, K. et al. J. Biol. Chem. 277, 22616 (2002).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Thr - Thr - Pro - Ser - Pro - Val - Pro - Thr - Thr - Ser - Thr - Thr - Ser - Ala - Pro - OH