Neurogranin is a postsynaptic protein that is expressed in dendritic cytoplasm. It regulates calcium-mediated signaling pathways and plays a key role in synaptic plasticity. Recently, neurogranin (48-76) was identified as the main neurogranin fragment in the human brain, and it was found that the content of neurogranin (48-76) in the cerebrospinal fluid of patients with Alzheimer's disease was elevated.
1. De Vos A., et.al., Alzh and Dement 4, 1-9 (2015)
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Ser - Gly - Glu - Cys - Gly - Arg - Lys - Gly - Pro - Gly - Pro - Gly - Gly - Pro - Gly - Gly - Ala - Gly - Gly - Ala - Arg - Gly - Gly - Ala - Gly - Gly - Gly - Pro - Ser - OH