This is a 17 to 26 amino acid fragment of p53, which is fluorescently labeled with an LC spacer. The p53 domain that binds to MD3M is also called the binding domain. The tumor suppressor protein p53 plays an important role in maintaining genome stability and preventing tumor development, FITC (Abs/Em=493nm/517nm)
Yu, G. et al. PNAS 103, 1227 (2006), Wang, Y. et al. J. Biol. Chem. 281, 24803 (2006), Kanovsky, M. et al. PNAS 98, 12438 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
FITC - LC - Glu - Thr - Phe - Ser - Asp - Leu - Trp - Lys - Leu - Leu - NH2