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Plasmodium falciparum Circumsporozoite Protein, (6NANP) PfCSP

Home/Catalog peptide/Plasmodium falciparum Circumsporozoite Protein, (6NANP) PfCSP
Plasmodium falciparum Circumsporozoite Protein, (6NANP) PfCSPAdmin2021-01-17T09:22:01+00:00
Product Name Plasmodium falciparum Circumsporozoite Protein, (6NANP) PfCSP
Purity HPLC>95%
Description P. falciparum circumsporozoite protein (PfCSP) is the most abundant antigen expressed on the surface of P. falciparum sporozoites. The middle part of the pre-erythropoiesis antigen contains 6 highly conserved immunodominant tetrapeptide repeats (NANP), and its N-terminal and C-terminal regions contain two key protection regions, respectively called RI and RII-plus . Both play a key role during the parasite invasion. PfCSP has always been the main target antigen in the development of pre-erythrocyte malaria vaccines, including subunit proteins with adjuvant or attenuated viral platforms. Studies have shown that high-titer antibodies against PfCSP are believed to block the invasion of blood-borne sporozoites on liver cells, thereby eliminating the development of blood-stage malaria.
Storage -20°C
References Zhang, Q. et al. Appl. Microbio. Biotech. 10, 1294 (2007).
Molecular Weight 2499.6
Sequence (One-Letter Code) NANPNANPNANPNANPNANPNANPC
Sequence (Three-Letter Code) H - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Asn - Ala - Asn - Pro - Cys - OH

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