This peptide is a PAR-1 antagonist which inhibited SFLLRNP induced platelet aggregation with an IC50 of 115 uM. Antagonists specific for the thrombin receptor can be promising compounds for treatment of thrombosis.
Fujita, T. et al. J Biochem 126, 174 (1999).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Ser - parafluoroPhe - Aad - Leu - Arg - Asn - Pro - NH2