The peptide increased membrane microviscosity, intracellular Ca2 + concentration and cell migration in circulating leukocytes, and oxygen production in monocytes and neutrophils. It can also induce apoptotic cell death and impaired L-type voltage sensitive calcium channel activity in GH3 cell lines. PrP (106 – 126) stimulated leukocyte migration in a dose-dependent manner.
Ref: Diomede, L. et al. Biochem. J. 320, 563 (1996); Florio, T. et al. J. Neurosci. Res. 54, 341 (1998).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Lys - Thr - Asn - Met - Lys - His - Met - Ala - Gly - Ala - Ala - Ala - Ala - Gly - Ala - Val - Val - Gly - Gly - Leu - Gly - OH