This peptide is from amino acid residues 1 to 21 of histone H3. It is phosphorylated at Thr-11 with a C-terminal GG linker, followed by biotinylated lysine. The phosphorylation of Thr-11 is carried out by a variety of enzymes, including protein kinase C related kinase 1 (PRK1) and serine/threonine protein kinase Chk1. This has many important functions, such as establishing a new chromatin marker for transcriptional regulation and regulating transcriptional inhibition induced by DNA damage. When the peptide purity is greater than 95%, the peptide is dissolved in distilled water at a concentration of 1 mg/ml, and lyophilized again into a powder form.
Metzger, E. et al. Nat Cell Biol 10, 53 (2010); Shimada, M. et al. Cell 132, 221 (2008).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys - Gln - Thr - Ala - Arg - Lys - Ser - pThr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Gly - Gly - Lys(Biotin) - NH2