This peptide is a 29 amino acid fragment in the rabies virus glycoprotein (RVG). Since neuroviruses infect brain cells through the blood-brain barrier, the same strategy can also be used to enter the central nervous system and deliver siRNA to the brain. The peptide specifically binds to the acetylcholine receptor expressed by neuronal cells.
Kumar, P. et al. Nature 448, 39 (2007).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Tyr - Thr - Ile - Trp - Met - Pro - Glu - Asn - Pro - Arg - Pro - Gly - Thr - Pro - Cys - Asp - Ile - Phe - Thr - Asn - Ser - Arg - Gly - Lys - Arg - Ala - Ser - Asn - Gly - OH