This peptide is a 3614-3643 amino acid fragment of Ryanodine receptor 1 (RyR1), also known as calmodulin-binding peptide (CaMBP), which belongs to a type of intracellular calcium channel. It is the main cellular mediator of calcium-induced calcium release (CICR) in animal cells. The ryanodine receptor itself is activated by intracellular calcium.
Kovaks, E. et al. J Biol Chem 285, 1799 (2010).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Lys - Ser - Lys - Lys - Ala - Val - Trp - His - Lys - Leu - Leu - Ser - Lys - Gln - Arg - Arg - Arg - Ala - Val - Val - Ala - Cys - Phe - Arg - Met - Thr - Pro - Leu - Tyr - Asn - OH