Recent advances in high-resolution sequencing have led to the discovery of unique peptides extracted from the mitochondrial genome. 1-2 At present, 8 peptides have been identified: human element, 12S-tRNA-c mitochondrial open reading frame (MOTS-c) and six small human-like peptides (SHLP1-6). 1-2 All these peptides are released from the mitochondria into the cytoplasm, and are related to extending lifespan, improving cell viability, reducing apoptosis and other beneficial functions. 1-3mots-c can reduce insulin resistance, reduce obesity, and promote homeostasis
1. Cobb L. J. et al., AGING 8 (4), 796-808 (2016). 2. Okada A. K. et al., Sci Reports 7 (7802), 1-10 (2017). 3. Lee C., et al., Cell Met 21, 443-454 (2015).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
NH2 - Met - Cys - His - Trp - Ala - Gly - Gly - Ala - Ser - Asn - Thr - Gly - Asp - Ala - Arg - Gly - Asp - Val - Phe - Gly - Lys - Gln - Ala - Gly - COOH