This is the 676 to 700 amino acids of steroid receptor coactivator (SRC1). This N-terminal biotinylated peptide is derived from the second LXXLL motif of SRC1. Coactivator proteins interact with ligand-related nuclear receptors and enhance transcription. The short amphipathic β-helical domain containing the LXXLL motif serves as the interaction interface between the co-activator molecule and the ligand-dependent activation function (AF-2) located at the end of the nuclear receptor ligand binding domain COOH ( LBD). The receptor binding domain of the co-activator SRC-1 is specifically recruited to the ligand binding domain of the Farnesian X receptor (FXR).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Biotin - Cys - Pro - Ser - Ser - His - Ser - Ser - Leu - Thr - Glu - Arg - His - Lys - Ile - Leu - His - Arg - Leu - Leu - Gln - Glu - Gly - Ser - Pro - Ser - OH