The synthetic peptide (Tat-Glur23Y) contains tyrosine residues, which can block the phosphorylation of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor endocytosis. Previous studies have shown that Tat-Glur23Y blocks the regulation of AMPA, thereby preventing long-term depression (LTD) in structures such as the nucleus accumbens and dorsal hippocampus
Dalton, G. et al. Neuropsychopharma. 33, 2416 (2008); Kim, J. et al. PNAS 104, 20955 (2007).