This peptide is derived from thrombospondin and represents a binding motif responsible for thrombospondin-CD36 interaction. It is cyclized through a disulfide bond. Thrombospondin is a matrix-bound glycoprotein involved in cancer metastasis, tumor adhesion, and angiogenesis. This peptide has been shown to competitively inhibit platelet aggregation and tumor metastasis.
Wakiyama, T. et al. Histol Histopathol 16, 345 (2001); Tsuzynski, G. et al. J Cell Biol 120, 513 (1993); Asch, A. et al. Biochem Biophys Res Commun 182, 1208 (1992).
Sequence (One-Letter Code)
CSVTCG (S-S Bonded)
Sequence (Three-Letter Code)
H - Cys - Ser - Val - Thr - Cys - Gly - OH (S - S Bonded)