siRNA (small interfering RNA), a short (usually 21 to 23-bp) double-stranded RNA (dsRNA) with phosphorylated 5′ ends and hydroxylated 3′ ends with two overhanging nucleotides, plays an important roal in RNAi owning to its ability to silence target genes. It has established its reputation in many fields including transposition, stem cell maintenance, defence against viruses, tumor therapy and tissue regeneration.
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