Precursor of the secreted amyloid β-protein (1-40) and (1-42). The identification of amyloid-β-protein (1-46) led to the identification of a zeta-cleavage site between the known γ- and ε-cleavage sites within the transmembrane domain of amyloid-β precursor protein (APP).
G.Zhao et al., J. Biol. Chem., 280, 37689 (2005) Y.Qi-Takahara et al., J. Neurosci., 25, 436 (2005) G.Zhao et al., J. Biol. Chem., 279, 50647 (2004)