Aβ 29-40, a C-terminal fragment of predominant Aβ 1-40, has physicochemical properties related to those of the fusion peptides of viral proteins. Aβ 29-40 can induce the fusion of liposomes in vitro. The apoE2 and apoE3 apolipoprotein isoforms are potent inhibitors of the fusogenic and aggregational properties of this peptide. Reciprocally this amyloid β-peptide interacts with apoE2 and apoE3 and decreases or disturbs their normal association with lipids. This domain of the amyloid β-protein could be critical for the amyloid-apoE interaction.
T.Pillot et al., Eur. J. Biochem., 243, 650 (1997)