This peptide is b-Amyloid 17 to 24 amino acids fragment. Several lines of evidence indicate that a region centering around positions 17 to 20 amino acids is important for b-Amyloid fibril formation. Destabilization of a helix covering residues 11–24, in particular residues 17–24, is critical for alpha-helix to b-strand conversion and fibril formation.
Päivio, A. et al. Prot. Sci. 13, 1251 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - OH