The natural peptide ARKRERTYSFGHHA (29944-1) is a synthetic substrate of AKT/PKB/Rac protein kinase. Phosphorylation occurs at the Ser site (Km=3.9µM). It also competitively inhibits histone H2B phosphorylation (Ki=12µM) by AKT.
Obata, T. et al. J. Biol. Chem. 275, 36108 (2000). Chan, TO. et al. Ann. Rev. Biochem. 68, 965 (1999).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Biotin - Ala - Arg - Lys - Arg - Glu - Arg - Thr - Tyr - Ser - Phe - Gly - His - His - Ala - OH