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Biotin-Glucagon-Like Peptide 1, GLP-1 (7-36), amide, human

Home/Catalog peptide/Biotin-Glucagon-Like Peptide 1, GLP-1 (7-36), amide, human
Biotin-Glucagon-Like Peptide 1, GLP-1 (7-36), amide, humanAdmin2021-01-07T07:02:40+00:00
Product Name Biotin-Glucagon-Like Peptide 1, GLP-1 (7-36), amide, human
Purity HPLC>95%
Description This GLP-1(7-36) amide is labeled with biotin at the n-terminus of the peptide. GLP-1(7-36)amide is an insulin-stimulating hormone that can cause glucose-dependent release of insulin by pancreatic cells. It is a cleavage product of GLP-1(1-36) amide peptide. GLP-1 (7-36) and GLP-1 (7-37) are also gastric motility (gastric emptying), suppression of plasma glucagon levels (glucose production), and may promote peripheral stimulation independently of insulin action Tissue satiety and stimulate glucose processing play a role. GLP-1(7-36) has a short half-life of less than 2 minutes. Like GIP, it can be rapidly degraded by dipeptidyl peptidase IV (DPP-4) and is widely expressed in many sites, including endothelial cells in small intestinal arteries. . DPP-4 degrades GLP-1 (7-36) into non-insulin GLP-1 (9-36) (some studies indicate that it may have weak insulin activity). As a result, the vast majority of GLP-1 (and GIP) are inactivated as insulin-promoting agents before entering the systemic circulation
Storage -20°C
References Drucker, D. et al. Proc Natl Acad Sci USA 84, 3434 (1987) Kieffer, T. and J. Habener, Endo Rev 20, 876 (1999) Deacon, CF. et. al. Hormone Metabolic Res 36,761 (2004), doi: 10.1055/s-2004-826160 Williams, JA. Pancreadepedia (2014), doi: 10.3998/panc.2014.7 Elahi, D. et. al. Obesity (Silver Spring) 16, 1501 (2008), doi: 10.1038/oby.2008.229 Ban, K. et. al. Endocrinol 151, 1520 (2010), doi: http://dx.doi.org/10.1210/en.2009-1197
Molecular Weight 3524
Sequence (One-Letter Code) Biotin-HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2
Sequence (Three-Letter Code) Biotin - His - Ala - Glu - Gly - Thr - Phe - Thr - Ser - Asp - Val - Ser - Ser - Tyr - Leu - Glu - Gly - Gln - Ala - Ala - Lys - Glu - Phe - Ile - Ala - Trp - Leu - Val - Lys - Gly - Arg - NH2

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