| Product Name | Cys(Npys)-(Arg)9 |
| Purity | HPLC>95% |
| Description | This is a peptide comprising of 9 Arginine residues and is synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group protects cysteine. This kind of modification has been used to render this peptide as a carrier peptide applicable in conjugation and cell permable studies. The S(Npys) group of this cysteine-containing 9R is capable of reacting selectively with the free thiol group of another cysteine-containing peptide to form an unsymmetrical disulfide bond. Coupling of sulfhydrils has been studied as an effective means to deliver/release therapeutics such as siRNA in the reducing environment within the cell. For example, in a study leukemic-specific SiRNA was delivered by the formation of immunocomplexes that consisted of targeted antibody conjugated to oligo-9-Arg peptides. |
| Storage | -20°C |
| References | Lee KY. et al. Mol & Cells. 29(5):457-462 (2010). |
| Molecular Weight | 1680.1 |
| Sequence (One-Letter Code) | C(Npys)RRRRRRRRR-NH2 |
| Sequence (Three-Letter Code) | H - Cys(Nyps) - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - NH2 |
Cys(Npys)-(Arg)9Admin2021-01-06T09:24:35+00:00
