This peptide is a fusion of A208, derived from murine laminin a1, and the active site of fibronectin (GRGDS), with a glycine spacer. This peptide forms amyloid-like fibrils and promotes formation of actin stress fibers that mediate fibroblast cell attachment, offering it potential as a bioadhesive for tissue regeneration and engineering. FN-A208 interacts with IKVAV receptors and integrins. Its activity is disrupted by the presence of EDTA.
Ohga, Y. et al. Biomater. 30, 6731 (2009). Kasai, S. et al. Biopolymers Pept. Sci. 76, 27 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Arg - Gly - Asp - Ser - Gly - Ala - Ala - Ser - Ile - Lys - Val - Ala - Val - Ser - Ala - Asp - Arg - OH