GALA is a 30 amino acid synthetic peptide with a repeating sequence of glutamic acid-alanine-leucine-alanine (EALA). It also contains histidine and tryptophan residues as spectroscopic probes. This peptide is designed to explore how the viral fusion protein sequence interacts with the cell membrane. The importance of helical length, hydrophobicity and hydrophobic moment on the formation, structure and function of ion channels was studied. The membrane interaction properties of GALA have been widely documented. The study of cytotoxic peptide analogs clarified the importance of peptide charge and the role of specific amino acids or amino acid arrays in the conformation, membrane binding affinity and pore-forming ability of these toxins.
Francois, N. et al. Biophys. J. 76, 2121 (1999), Li, W. et al. Adv. Drug Del. Rev.56, 967 (2004).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Trp - Glu - Ala - Ala - Leu - Ala - Glu - Ala - Leu - Ala - Glu - Ala - Leu - Ala - Glu - His - Leu - Ala - Glu - Ala - Leu - Ala - Glu - Ala - Leu - Glu - Ala - Leu - Ala - Ala - OH