This fibrinogen-derived inhibitory peptide attenuates microglia activation and suppresses relapsing paralysis in multiple sclerosis (MS). Fibrinogen is a regulator of microglia activation and interaction of fibrinogen with the microglia integrin receptor Mac-1. Because blocking fibrinogen–Mac-1 interactions affects the pro-inflammatory but not the pro-coagulant properties of fibrinogen, targeting this gamma- fibrinogen epitope could represent a potential therapeutic strategy for MS and other neuroinflammatory diseases associated with blood-brain barrier disruption and microglia activation.
Adams, R. et al. J. Exp. Med. Published online 5 March 2007 doi:10.1084/jem.20061931
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Tyr - Ser - Met - Lys - Glu - Thr - Thr - Met - Lys - Ile - Ile - Pro - Phe - Asn - Arg - Leu - Ser - Ile - Gly - OH