Gastrin-1 is also called gastrin-17 or "little gastrin". The secretion of gastrin is caused by food intake, causing the release of gastric acid in the stomach. Secreted by G cells in the gastric mucosa, it is one of the main bioactive forms of gastrin in tissues and plasma (the other bioactive form is gastrin-34 or macrogastrin-Cat#AS-20747). Both gastrin-17 and gastrin-34 are carboxy amidated and partially tyrosine sulfated. The binding of gastrin to CCK2/gastrin receptor requires carboxy amidation, but binding to the receptor does not require sulfation. Gastrin binds to the CCK2/gastrin receptor on the parietal cells, causing the parietal cells to secrete hydrochloric acid (HCl), and stimulates the expression of lectin-like protein Reg by activating PKC and RhoA. Gastrin also plays a role in the release of histamine and pepsinogen.
Choudhury, A. et al. Hoppe-Seylers Z Physiol Chem 361, 1719 (1980) Niederle, B. Wien Klin Wochenschr 119, 561 (2007), doi: 10.1007/s00508-007-0897-x. O’Connor A. et. al. Digestive Dis 32, 186 (2014), doi: 10.1159/000357848 Dockray, G. et.al. Pflügers Archiv 449,344 (2005) Bundgaard, JR et al. J Biol Chem 272, 21700 (1997), doi: 10.1074/jbc.272.35.21700 Yakabi, K. et al. World J Gastroenterol 14, 6334 (2008), doi: 10.3748/wjg.14.6334
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Pyr - Gly - Pro - Trp - Leu - Glu - Glu - Glu - Glu - Glu - Ala - Tyr - Gly - Trp - Met - Asp - Phe - NH2