Glucagon-Like Peptide 1, GLP-1 (7-36)-Lys(Biotin), amide, human
This GLP-1(7-36) amide contains an additional lysine (K) residue at its n-terminus, and biotin is coupled to the lysine side chain. GLP-1(7-36)amide is an insulin-stimulating hormone that can cause glucose-dependent release of insulin by pancreatic cells. It is a cleavage product of GLP-1(1-36) amide peptide. GLP-1 (7-36) and GLP-1 (7-37) are also involved in gastric motility (gastric emptying), suppression of plasma glucagon levels (glucose production), and may promote the periphery without the action of insulin Tissues play a role in satiety and stimulation of glucose processing. GLP-1(7-36) has a short half-life of less than 2 minutes. Like GIP, it can be rapidly degraded by dipeptidyl peptidase IV (DPP-4) and is widely expressed in many sites, including endothelial cells in small intestinal arteries. . DPP-4 degrades GLP-1 (7-36) into non-insulin GLP-1 (9-36) (some studies indicate that it may have weaker insulin activity). As a result, the vast majority of GLP-1 (and GIP) are inactivated as insulin growth promoters before entering the systemic circulation.
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Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - His - Ala - Glu - Gly - Thr - Phe - Thr - Ser - Asp - Val - Ser - Ser - Tyr - Leu - Glu - Gly - Gln - Ala - Ala - Lys - Glu - Phe - Ile - Ala - Trp - Leu - Val - Lys - Gly - Arg - Lys(Biotin) - NH2