The insulin b-chain peptide binds to the class II histocompatibility complex (MHC) allele I-Ag7. Many autoimmune diseases are related to class II proteins encoded by MHC. Type 1 diabetes, or insulin-dependent diabetes, is a T-cell-mediated disease that causes autoimmunity to destroy pancreatic cells, leading to high blood sugar. This insulin B peptide may be a self-antigen candidate and may cause disease. Immunization of mice with this peptide can cause autoantibodies and meningitis.
Devendra, D. et al. Diabetes 54, 2549 (2005). Starwalt, S. et al. Protein Eng. 16, 147 (2003); Lee, L. et al. PNAS 102, 15995 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - His - Leu - Val - Glu - Ala - Leu - Tyr - Leu - Val - Cys - Gly - Glu - Arg - Gly - OH