The peptide is a 1 to 20 amino acid fragment of the photoreceptor retinol-binding protein (IRBP). IRBP is a 140 kDa glycolipoprotein located in the photoreceptor matrix between the neural retina and the retinal pigment epithelium. Human IRBP peptide 1-20 contains the main epitope of the H-2b haplotype. Immunization with IRBP (1-20) can induce experimental autoimmune uveoretinitis (EAU) disease mediated by T cells. The disease pathology induced by adoptive transfer of the peptide or the peptide-specific cells is similar to the disease induced by the entire IRBP protein.
Avichezer, D. et al. Invest. Ophthalmol. Visual Sci. 41, 127 (2000).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Pro - Thr - His - Leu - Phe - Gln - Pro - Ser - Leu - Val - Leu - Asp - Met - Ala - Lys - Val - Leu - Leu - Asp - OH