Bradykinins (BK) and related kinins are potent inflammatory mediators produced during acute and chronic inflammation. The two main ‘kinins’ in mammals are the nonapeptide bradykinin, BK (1-9) and the decapeptide kallidin (KD), [Lys0]-BK(1-10). Their biological actions are mediated by two distinct receptors, termed B1 and B2. BK and [Lys0]-BK are peptides which are released at high nanomolar concentrations into the tear-film of ocular allergic patients.
Altamura, M. et al Regul. Pept. 80, 13 (1999); Siebeck, M. et al. Immunopharmacol. 40, 49 (1998); Wiernas, T. et al. Br. J. Pharmacol. 121, 649 (1997).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Lys - Arg - Pro - Pro - Gly - Phe - Ser - Pro - Phe - Arg - OH