This peptide is histone H3, acetylated at Lys4. It is biotinylated via a C-terminal GGK connector. This post-translationally modified histone peptide is present in humans, Tetrahymena thermophila, Schizosaccharomyces bom and mice. The acetylation of Lys4 is controlled by Mst1. This peptide acts as a color gamut switch by weakening the interaction between Chp1 and H3K9 methylation tails, thereby promoting the binding of HP1 protein. When the peptide purity is greater than 95%, the peptide is dissolved in distilled water at a concentration of 1 mg/ml, and lyophilized again into a powder form.
Xhemalce, B. and T Kouzarides. Gene Dev 24, 647 (2010); Garcia, B. et al. J Biol Chem 282, 7641 (2007).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys(Ac) - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Gly - Gly - Lys(biotin) - OH