This peptide is histone H4 (1-21), acetylated at lysine 5, 8, 12, and 16. It contains a C-terminal GG linker followed by a biotinylated lysine. In general, histone H4 acetylation is associated with increased DNA replication during mitosis, although the different combinations of acetylation at specific sites are selective for specific processes. When the peptide purity is greater than 95%, the peptide is dissolved in distilled water at a concentration of 1 mg/ml, and lyophilized again into a powder form.
Jasencakova, Z. et al. Plant Cell 12, 2087 (2000); Johnson, C. et al. Nucl Acids Res 26, 994 (1998).