This peptide is histone H4 (1-25), acetylated at Lys8. It is biotinylated via a C-terminal gsk connector. Acetylation at Lys8 is essential for the transcriptional activation of the SWI/SNF (switch/sucrose non-fermentation) chromatin remodeling complex through the bromouracil-containing protein BRG1. When the peptide purity is greater than 95%, the peptide is dissolved in distilled water at a concentration of 1 mg/ml, and lyophilized again into a powder form.
Kurdistani, S. and M. Grunstein Nat Rev Mol Cell Biol 4, 276 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys(Ac) - Gly - Leu - Gly - Lys - Gly - Gly - Ala - Lys - Arg - His - Arg - Lys - Val - Leu - Arg - Asp - Asn - Gly - Ser - Gly - Ser - Lys(Biotin) - OH