The histone 3 peptide is acetylated at position 9 of the lysine residue. In xenogeneic glioblastomas expressing O6-methylguanine DNA methyltransferase (MGMT), the increase in H3K9-ac was observed to be related to histone acetylation and up-regulation of MGMT, thus revealing chromatin-mediated The mechanism of up-regulation of MGMT may guide epigenetic therapy to influence the development mechanism of drug resistance in glioblastoma.
Kitange GJ. et al. Clin Can Res. 18:4070 (2012)
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys - Gln - Thr - Ala - Arg - Lys(Ac) - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Thr - Lys - Ala - OH