This is Lys whose histone H3 (1-21) is monomethylated at Lys9 and then biotinylated at its C-terminus. Lys9 monomethylated histone H3 is related to the autosomal silent chromatin domain. This single methylation state is also the preferred substrate for Suv39h1 and Suv39h2, which are methyltransferases that catalyze the trimethylation of Lys9. When the peptide purity is greater than 95%, the peptide is dissolved in distilled water at a concentration of 1 mg/ml, and lyophilized again into powder.
Grewal, S. et al. Curr Opin Cell Biol 16, 230 (2004); Rice, J. et al. Mol Cell 12, 1591 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys - Gln - Thr - Ala - Arg - Lys(Me1) - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Lys(Biotin) - OH