This peptide is histone H4 (1-23). It is trimethylated with a C-terminal GG linker at lysine 20, followed by biotinylated lysine. The methylation of histone H4 on lysine 20 plays a key role in gene expression, cell cycle progression and DNA repair. The trimethylation of histone H4 on lysine 20 maintains the heterochromatin structure. When the peptide purity is greater than 95%, the peptide is dissolved in distilled water at a concentration of 1 mg/ml, and lyophilized again into a powder form.
Wang, Y., Jia, S., Epigenetics 4, 5 (2009).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys - Gly - Gly - Ala - Lys - Arg - His - Arg - Lys(Me3) - Val - Leu - Arg - Gly - Gly - Lys(Biotin) - NH2