This peptide is histone H3 trimethylated at 4 lysines, which is related to transcription, especially marking the transcription start site of actively transcribed genes. This peptide can be demethylated by the polyamine 1 (JARID1) or the lysine demethylase (Jumonji) of the lysine demethylase 5 (KDM5) family with rich interaction.
1, Blair LP. et al. Cancers. 3(1):1383-1404 (2011) 2, Kok, R. et al. Bioconjug Chem 13, (2002).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys(Me3) - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - OH