This glycopeptide is an N-acetyl galactosamine (GalNAc)-modified MUC5AC mucin peptide containing the single site of threonine 13 labeled with GalNAc (T*). Polypeptide N-acetylgalactosaminyltransferase (ppGaNTase) catalyzes the transfer of GalNAc from the nucleotide sugar UDP-GalNAc to threonine. The MUC5AC gene is mainly expressed in gastric and tracheo-bronchial mucosae, and some tumors.
Ten Hagen, K. et al. J. Biol. Chem. 277, 22616 (2002).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Thr - Thr - Pro - Ser - Pro - Val - Pro - Thr - Thr - Ser - Thr - Thr* - Ser - Ala - Pro - OH (Thr* = GalNac labeled Thr)