This is the 81-111 amino acid fragment of NY-ESO-1. NY-ESO-1 antigen is expressed in many different histological types of tumors (including breast, prostate, lung, and melanoma) and male germline cells, but not in other normal tissues. NY-ESO-1 encodes MHC class I and class II restricted peptides, which are expressed by a variety of cancers and recognized by T cells. The peptide is a pan-MHC class II restricted sequence, which can bind to multiple HLA-DR and HLA-DP4 molecules, including HLA-DRB1*0101, 0401, 0701, 1101 and HLA-DPB1*0401 and 0402 molecules.
Mandic, M. et al. J. Immunol. 174, 1751 (2005).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Leu - Leu - Glu - Phe - Tyr - Leu - Ala - Met - Pro - Phe - Ala - Thr - Pro - Met - Glu - Ala - Glu - Leu - Ala - Arg - Arg - Ser - Leu - Ala - Gln - OH