This peptide is a potent antagonist of pacap38 and is more effective and selective than PACAP (6-27) in inhibiting the pituitary adenylate cyclase stimulated by PACAP-27. The Ki values of enzyme inhibition were 7nM and 150nm, respectively.
Ref: Robberecht, P. et al. Eur. J. Biochem. 207, 239 (1992).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Phe - Thr - Asp - Ser - Tyr - Ser - Arg - Tyr - Arg - Lys - Gln - Met - Ala - Val - Lys - Lys - Tyr - Leu - Ala - Ala - Val - Leu - Gly - Lys - Arg - Tyr - Lys - Gln - Arg - Val - Lys - Asn - Lys - NH2