This is a pannexin-1 (Panx1) mimic blocking peptide. Pannexin-1 is a recently identified membrane protein. When overexpressed in two adjacent oocytes or mammalian epithelial cell lines, it can form gap junction-like connections to allow the dye to pass between cells. The blockade of pannexin-1 in macrophages that endogenously express the ATP-gated P2X7 receptor (P2X7R) prevents the initial dye uptake, but does not block the ion current, and also blocks the processing and release of interleukin-1 . (IL-1?) In response to P2X7R activation.
Pelegrin, P. et al. EMBO. J. 25, 5071 (2006); Pelegrin, P. et al.t J. Biol. Chem. 282, 2386 (2007).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Trp - Arg - Gln - Ala - Ala - Phe - Val - Asp - Ser - Tyr - OH