This protease-activated receptor-1 (PAR-1) selective peptide induces cyclooxygenase-2 (COX-2) protein and mRNA expression in human endothelial cells. Studies show that intratracheal instillation of the PAR1-specific peptide increases lung edema during high-tidal-volume ventilation
Syeda,, F. et al. J. Biol. Chem 281, 11792 (2006); Jenkins, R. et al. J. Clin. Invest; 116, 1606 (2006).