Uroguanylin is a natriuretic peptide, a hormone that regulates sodium excretion by the kidney when excess NaCl is consumed. Uroguanylin and guanylin are related peptides that activate common guanylate cyclase signaling molecules in the intestine and kidney. Uroguanylin was isolated from urine and duodenum but was not detected in extracts from the colon of rats.
Sequence (One-Letter Code)
TDECELCINVACTGC (Disulfide bonds between Cys4-Cys12 and Cys7-Cys15)
Sequence (Three-Letter Code)
H - Thr - Asp - Glu - Cys - Glu - Leu - Cys - Ile - Asn - Val - Ala - Cys - Thr - Gly - Cys - OH (Disulfide bonds between Cys4 - Cys12 and Cys7 - Cys15)