| Product Name | Dermcidin, DCD-1L |
| Purity | HPLC>95% |
| Description | The protein dermcidin expressed in the sweat glands is secreted into the sweat and transported to the epidermal surface. The concomitant processing of the protein yields a broad-spectrum antimicrobial 47 amino acid peptide, dermcidin-1 (DCD-1). Dermcidin and naturally occurring fragments as DCD-1L do not perturb membrane permeability and bind to distinct surface molecules. Niyonsaba et al. have reported that DCD-1L stimulates keratinocytes to generate cytokines and chemokines such as TNF-α, IL-8, CXCL10, and CCL20. |
| Storage | -20°C |
| References | F.Niyonsaba et al., Br. J. Dermatol., 160, 243 (2009) H.Steffen et al., Antimicrob. Agents Chemother., 50, 2608 (2006) B.Schittek et al., Nat. Immunol., 2, 1133 (2001) |
| Molecular Weight | 4818.50 |
| Sequence (One-Letter Code) | SSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL |
| Sequence (Three-Letter Code) | H-Ser-Ser-Leu-Leu-Glu-Lys-Gly-Leu-Asp-Gly-Ala-Lys-Lys-Ala-Val-Gly-Gly-Leu-Gly-Lys-Leu-Gly-Lys-Asp-Ala-Val-Glu-Asp-Leu-Glu-Ser-Val-Gly-Lys-Gly-Ala-Val-His-Asp-Val-Lys-Asp-Val-Leu-Asp-Ser-Val-Leu-OH |
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