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Dermcidin, DCD-1L

Home/Antimicrobial Peptides/Dermcidin, DCD-1L
Dermcidin, DCD-1LAdmin2020-08-25T03:18:18+00:00
Product Name Dermcidin, DCD-1L
Purity HPLC>95%
Description The protein dermcidin expressed in the sweat glands is secreted into the sweat and transported to the epidermal surface. The concomitant processing of the protein yields a broad-spectrum antimicrobial 47 amino acid peptide, dermcidin-1 (DCD-1). Dermcidin and naturally occurring fragments as DCD-1L do not perturb membrane permeability and bind to distinct surface molecules. Niyonsaba et al. have reported that DCD-1L stimulates keratinocytes to generate cytokines and chemokines such as TNF-α, IL-8, CXCL10, and CCL20.
Storage -20°C
References F.Niyonsaba et al., Br. J. Dermatol., 160, 243 (2009) H.Steffen et al., Antimicrob. Agents Chemother., 50, 2608 (2006) B.Schittek et al., Nat. Immunol., 2, 1133 (2001)
Molecular Weight 4818.50
Sequence (One-Letter Code) SSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL
Sequence (Three-Letter Code) H-Ser-Ser-Leu-Leu-Glu-Lys-Gly-Leu-Asp-Gly-Ala-Lys-Lys-Ala-Val-Gly-Gly-Leu-Gly-Lys-Leu-Gly-Lys-Asp-Ala-Val-Glu-Asp-Leu-Glu-Ser-Val-Gly-Lys-Gly-Ala-Val-His-Asp-Val-Lys-Asp-Val-Leu-Asp-Ser-Val-Leu-OH

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