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Endotoxin Inhibitor

Home/Antimicrobial Peptides/Endotoxin Inhibitor
Endotoxin InhibitorAdmin2020-08-25T02:32:12+00:00
Product Name Endotoxin Inhibitor
Purity HPLC>95%
Description The cyclic peptide KTKCKFLKKC has ben shown to form a strong complex with lipid A, the toxic component of the endotoxin lipopolysaccharide (LPS) with Ka = 0.56 · 10⁷ M⁻¹. It detoxifies LPS in vitro and prevents LPS-induced cytokine release and lethality in vivo. Furthermore, it shows neither antibiotic activity nor toxicity and might therefore be useful in the prophylaxis and treatment of LPS-mediated diseases. KTKCKFLKKC bears a structural resemblance to the peptide antibiotic and endotoxin inhibitor polymyxin B. It could be of use as an adjuvant for antibiotic therapy.
Storage -20°C
References M.Vaara and M.Porro, Antimicrob. Agents Chemother., 40, 1801 (1996) A.Rustici et al., Science, 259, 361 (1993)
Molecular Weight 1224.60
Sequence (One-Letter Code) KTKCKFLKKC(Disulfide bond)
Sequence (Three-Letter Code) H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-OH (Disulfide bond)

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